Population Selection

Population:

Real Population

Virtual Population

Inclusion Criteria Selection

Baseline Age Interval (Years):

Baseline 6-Minute Walk Distance (m):

Baseline Fat Fraction of Soleus Muscle:

Baseline Fat Fraction of Vastus Laterails Muscle:

Proportion of Steroid Users (%)

The Number of Individuals in Available Sampling Pool

Distribution of Baseline Scores

Select a Measure

Distribution of Baseline Age

Distribution of Steroid Use

Change Power Curve Settings

Enter Maximum Sample Size

Select Maximum Study Duration

Select Level of Significance

Enter Number of Replicates

Current Settings

Power Curve

Project Support

All the data presented here were collected as part of the ImagingNMD project supported by NIH NIAMS/NINDS (R01AR056973). The modeling and simulation work was supported by NIH NCATS (R21TR004006), ImagingNMD, the University of Florida Clinical and Translational Science Institute (UL1TR001427), and Duchenne Imaging Biomarker Steering Committee. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank Critical Path Institute for their feedback and support. We also thank Simulations Plus for the free usage of Simulx, which runs the simulation, and David Hemond (University of Florida) for the GUI server setup.

Developers

The app was developed by Jongjin Kim (Research Scientist, University of Florida) and Dr. Sarah Kim (Assistant Professor, University of Florida) et al. on behalf of the University of Florida, ImagingNMD, and the Duchenne Imaging Biomarker Steering Committee. E-mail: sarahkim@cop.ufl.edu with questions or comments.

Dataset Access

In accordance with our informed consent form, researchers will be required to apply for access to the data set by submitting the following information, which will be reviewed by an Executive Committee: i) Researcher name(s) and institutional affiliation(s) and ii) A brief proposal outlining how the data will be used. The request should be submitted to Dr. Krista Vandenborne (the Director of ImagingNMD) via Email: kvandenb@phhp.ufl.edu . If shared data are used in subsequent publications, the original funding source (AR056973) and the ImagingNMD network will need to be acknowledged and published methodology developed during the course of the study cited, as appropriate. https://imagingnmd.org/data-sharing/ .

DMD Clinical Trial Simulator

Simulate Clinical Trials on Individuals with Duchenne Muscular Dystrophy